Peptide Encyclopedia & Longevity Stack Builder

Peptide

BPC-157

BPC-157 administration Accelerated wound healing

Upregulation of VEGF and eNOS, promoting angiogenesis and blood flow to injured tissue

Confidence

90%

BPC-157 administration Protection of gastric mucosa

Modulation of nitric oxide synthase, regulation of prostaglandin synthesis, and antioxidant activity

Confidence

85%

BPC-157 administration Tendon and ligament healing

Increased fibroblast proliferation, collagen synthesis, and angiogenesis at the injury site

Confidence

85%

BPC-157 administration Reduced systemic inflammation

Downregulation of pro-inflammatory cytokines IL-6, TNF-alpha, and NF-kB pathway

Confidence

80%

BPC-157 administration Neuroprotection

Protection of dopaminergic neurons, reduction of oxidative stress in neural tissue

Confidence

70%

Peptide

TB-500

TB-500 administration Enhanced tissue regeneration

Actin sequestration enabling cell migration and differentiation

Confidence

85%

TB-500 administration Angiogenesis

Upregulation of VEGF and activation of the Akt signaling pathway

Confidence

85%

TB-500 administration Reduced inflammation

Downregulation of pro-inflammatory cytokines and modulation of immune cell migration

Confidence

80%

TB-500 administration Cardiac repair post-infarction

Promotion of cardiomyocyte survival, activation of epicardial progenitor cells

Confidence

75%

Peptide

GHK-Cu

GHK-Cu administration Increased collagen synthesis

Activation of matrix metalloproteinases and fibroblast collagen production

Confidence

90%

GHK-Cu administration Reduced wrinkle depth and improved skin elasticity

Copper-dependent superoxide dismutase activation, increased collagen and elastin synthesis

Confidence

85%

GHK-Cu administration Wound healing acceleration

Attraction of immune cells to wound site, promotion of angiogenesis and granulation tissue formation

Confidence

85%

GHK-Cu administration Antioxidant protection

Upregulation of antioxidant enzymes including catalase and superoxide dismutase

Confidence

80%

GHK-Cu administration Hair growth stimulation

Increased hair follicle size, prolonged anagen phase, reduced TGF-beta signaling

Confidence

70%

Peptide

Epitalon

Epitalon administration Telomerase activation

Increased expression of human telomerase reverse transcriptase (hTERT)

Confidence

75%

Epitalon administration Extended lifespan in model organisms

Telomere elongation, reduced cellular senescence, improved mitochondrial function

Confidence

65%

Epitalon administration Restored pineal gland function

Normalization of melatonin secretion patterns, improved circadian rhythm regulation

Confidence

70%

Epitalon administration Improved immune function in aging

Restoration of T-cell function, reduced age-related immune decline

Confidence

65%

Peptide

MOTS-c

MOTS-c supplementation Improved insulin sensitivity

AMPK activation in skeletal muscle, enhanced glucose uptake, and reduced lipid accumulation

Confidence

80%

MOTS-c supplementation Increased mitochondrial biogenesis

Activation of PGC-1alpha, increased mitochondrial DNA replication

Confidence

75%

MOTS-c supplementation Lifespan extension in mice

Improved metabolic health, reduced age-related inflammation, maintained mitochondrial function

Confidence

70%

MOTS-c supplementation Reduced obesity and metabolic syndrome

AMPK-dependent metabolic reprogramming, increased fatty acid oxidation

Confidence

75%

Peptide

Humanin

Humanin overexpression Neuroprotection against Alzheimer's pathology

Binding to IGFBP-3, inhibition of Bax-mediated apoptosis, reduced amyloid-beta toxicity

Confidence

75%

Humanin administration Cardioprotection during ischemia

STAT3 activation, reduced oxidative stress, maintained mitochondrial membrane potential

Confidence

70%

Humanin administration Reduced apoptosis in aging cells

Inhibition of mitochondrial permeability transition pore, suppression of caspase activation

Confidence

80%

Humanin administration Improved metabolic health

Enhanced insulin sensitivity, reduced inflammation through SOCS-3 pathway

Confidence

70%

Peptide

Semax

Semax administration Enhanced cognitive function and memory

Increased BDNF and NGF expression, enhanced neuroplasticity and synaptic transmission

Confidence

80%

Semax administration Reduced anxiety and stress response

Modulation of the HPA axis, reduced cortisol levels, increased serotonin activity

Confidence

75%

Semax administration Neuroprotection

Reduced oxidative stress, increased antioxidant enzyme activity in neural tissue

Confidence

80%

Semax administration Improved attention and focus

Increased dopamine and norepinephrine activity in prefrontal cortex

Confidence

75%

Peptide

Selank

Selank administration Anxiolytic effects without sedation

Modulation of GABA-A receptor subunits, increased serotonin 5-HT1A receptor activity

Confidence

80%

Selank administration Enhanced cognitive function

Increased BDNF expression, enhanced neuroplasticity and hippocampal neurogenesis

Confidence

75%

Selank administration Reduced inflammation in neural tissue

Modulation of pro-inflammatory cytokines, reduced NF-kB activation

Confidence

70%

Selank administration Improved sleep quality

Normalization of circadian rhythms, reduced hyperarousal of the HPA axis

Confidence

70%

Peptide

Cerebrolysin

Cerebrolysin administration Enhanced neuroplasticity and cognitive recovery

BDNF and GDNF upregulation, increased synaptic density and dendritic branching

Confidence

85%

Cerebrolysin administration Reduced amyloid-beta accumulation

Inhibition of amyloid precursor protein processing, enhanced clearance of amyloid plaques

Confidence

75%

Cerebrolysin administration Stroke recovery improvement

Reduced infarct volume, enhanced angiogenesis and neurogenesis in peri-infarct tissue

Confidence

80%

Cerebrolysin administration Reduced neuroinflammation

Downregulation of microglial activation, reduced pro-inflammatory cytokine production

Confidence

75%

Peptide

Thymosin Alpha-1

Thymosin Alpha-1 administration Enhanced T-cell function

Increased T-cell proliferation, differentiation, and activation via TLR9 signaling

Confidence

85%

Thymosin Alpha-1 administration Improved immune response to infection

Enhanced NK cell activity, increased cytokine production, improved antigen presentation

Confidence

85%

Thymosin Alpha-1 administration Reduced inflammation in autoimmune conditions

Regulation of Th1/Th2 balance, increased anti-inflammatory cytokine production

Confidence

70%

Thymosin Alpha-1 administration Improved vaccine response in elderly

Restoration of age-related immune decline, enhanced antibody production

Confidence

80%

Peptide

AOD9604

AOD9604 administration Increased fat metabolism

Activation of lipolysis via beta-adrenergic receptors, increased fatty acid oxidation

Confidence

75%

AOD9604 administration Reduced fat accumulation

Inhibition of lipogenesis, reduced triglyceride storage in adipose tissue

Confidence

75%

AOD9604 administration Improved metabolic rate

Increased thermogenesis, enhanced mitochondrial uncoupling in brown adipose tissue

Confidence

70%

Peptide

NAD+ and Mitochondrial Health

NAD+ decline with age Reduced mitochondrial function and cellular energy

Decreased NAD+/NADH ratio impairs sirtuin activity, reduces ATP production, increases oxidative stress

Confidence

90%

NMN/NR supplementation Increased NAD+ levels and improved mitochondrial function

NAD+ precursor conversion via salvage pathway, activation of SIRT1-7 deacetylases

Confidence

85%

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Peptide Encyclopedia & Longevity Stacking